Engystol ®

Engystol® is produced in Germany and marketed by Biologische Heilmittel Heel GmbH for more than 60 years and marketed in Greece by A.S.K. Pharmaceutical, as an OTC medicine in tablet form.

The aim of treatment with Engystol® is to activate and support the body’s endogenous defense mechanisms and thus to strengthen the natural immune response in cases of upper respiratory viral infection, resulting in milder symptoms and shorter recovery times. Taken either preventively or at the first signs of a cold, Engystol® may prevent the development of acute symptoms(fever, bone aches, muscle aches).

Patient Instructions Leaflet


Natural relief for the symptoms of the common cold.

Vincetoxicum hirundinaria

Stimulation of the endogenous defence mechanisms with sympathetic action.


Reactant in all chronic diseases e.g. acute and chronic inflammation of the respiratory, hepatic and gastrointestinal system, catarrh of the upper respiratory tract, dyspnea, bronchial asthma, throbbing headache.


For the whole family (children above 6 years)

High risk persons or persons susceptible to seasonal viral infections.

Option for long term treatment.

Option for monotherapy or combination treatment.

Persons with otitis, sinusitis or dermatitis should consult their doctor before using Engystol.

Health professionals

  • Engystol Leaflet
  • Citations
Engystol Leaflet
  1. Product Approved by EOF-Marketing Authorization Number 61574/18 / 9-5-2019.
  2. Wronski S, Dannenmaier J, Schild S, et al. Engystol reduces onset of experimental respiratory syncytial virus-induced respiratory inflammation in mice by modulating macrophage phagocytic capacity. PLoS One 2018;13(4): e0195822. doi:10.1371.journal.pone.0195822
  3. Wagner H, Jurcic K, Doenicke A, Behrens N. Influence of Homeopathic Drug Preparations on the Phagocytosis Capabiblity of Granulocytes: In-vitro tests and controlled single-blind studies. Biol Ther. 1993;11(1):43-49.
  4. Enbergs H. Effects of the homeopathic preparation Engystol on interferon-gamma production by human T-lymphocytes. Immunol Invest. 2006;35(1):19-27. doi:10.1080/08820130500496753
  5. Roeska K, Seilheimer B. Antiviral activity of Engystol(R) and Gripp-Heel(R): an in-vitro assessment. J Immune Based Ther Vaccines. 2010;8(1):6. doi:10.1186/1476-8518-8-6
  6. Schmiedel V, Klein P. A complex homeopathic preparation for the symptomatic treatment of upper respiratory infections associated with the common cold: An observational study. Explore. 2006;2(2):109-114. doi:10.1016/jexplore.2005.12.008
  7. Torbicka E, Brzozowska-Binda A, Wilczynski J, Uzerowicz A. RSV infections in infants: therapy with a homeopathic preparation. Biomed Ther. 1998;16(4):256-260.
  8. Herzberger G, Weiser M. Homeopathic treatment of infections of various origins: a prospective study. Biomed Ther. 1997;15(4): 123-127.
  9. Heilmann A. A combination injection preparation as a prophylactic for flu and common colds. Biol Ther. 1994;12(4) :249-253.
  10. Oberbaum M, Glatthaar-Saalmuller B, Stolt P, Weiser M. Antiviral activity of Engystol: an in vitro analysis. J Altern Complement Med. 2005;11(5):855-862. doi:10.1089/acm.2005.11.855.
  11. Matusiewicz R. The effect of a homeopathic preparation on the clinical condition of patients with corticosteroid-dependent bronchial asthma. Biomed Ther 1997;XV(3): 70-74.
  12. Biotherapeutic Index: A Medical Compendium for Health Care Professionals. 8th rev ed. Queenswood, Pretoria, South Africa: Briza Publications; 2012.

Report side effects

  • How can I report side effects?
How can I report side effects?

Reporting of suspected adverse reactions.

Healthcare professionals are asked to report any suspected adverse reactions via the National Organization of Medicines. If you are a patient and you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in the package leaflet. You can report adverse reactions with the following options :

1)Electronic submission through EOF’s website
2) Dispatching the Yellow card in hard copy via mail to EOF to the Department of Adverse Reactions (Mesogeion 284, Cholargos 15562)
3) Communication with the Department of Adverse Reactions via telephone :
4) Submission of the yellow card via fax at 210.6549.585


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